Synergy between fosfomycin and arenaemycin.

In Vitro Synergistic Activity of Imipenem and Fosfomycin against Methicillin-resistant Staphylococcus Aureus

The in vitro activity of imipenem in combination with fosfomycin against 17 clinical isolates of methicillin-resistant Staphylococcus aureus from hospitalized patients was investigated by checkerboard and time-kill studies. Of the 17 strains tested, checkerboard studies revealed synergy in 14(82.3%)and indifference in 3(17.6%): the time-kill studies also revealed synergy in 14 of 14 strains at ...

In vitro synergy testing of novel antimicrobial combination therapies against Neisseria gonorrhoeae.

BACKGROUND Antimicrobial-resistant Neisseria gonorrhoeae is a major public health threat. Current CDC treatment guidelines for uncomplicated gonorrhoea recommend only ceftriaxone plus either azithromycin or doxycycline. Additional treatment options are needed. METHODS We used antibiotic gradient synergy testing (the Etest) to evaluate antimicrobial combinations that included a third-generatio...

Fosfomycin synergy in vitro with amoxicillin, daptomycin, and linezolid against vancomycin-resistant Enterococcus faecium from renal transplant patients with infected urinary stents.

Fosfomycin is a potential option for vancomycin-resistant enterococcus (VRE) infections despite limited in vitro and clinical data. In this study, 32 VRE isolates from renal transplant patients with urinary stent infections were susceptible to fosfomycin, daptomycin, and linezolid and resistant to amoxicillin, minocycline, and nitrofurantoin based on their MIC(50)s and MIC(90)s. Fosfomycin was ...

In vitro evaluation of antibiotic synergy for NDM-1-producing Enterobacteriaceae.

OBJECTIVES To analyse the in vitro activity of colistin, fosfomycin and tigecycline alone or in combination against enterobacterial NDM-1 producers. METHODS MIC values of colistin, fosfomycin and tigecycline were determined for 28 NDM-1-producing enterobacterial isolates. In vitro synergy combination testing was performed for eight clinical isolates and one Escherichia coli transconjugant (si...

In Vitro Synergistic Activity of Biapenem Combination with Sulbactam, Colistin, and Fosfomycin Sodium Against Multidrug-resistant Acinetobacter baumannii Isolates from Tertiarycare Hospitals in Thailand